CDISC Pilot Replication
A modern rebuild of the CDISC pilot clinical tables
This site documents the CDISC Pilot Replication project: a full reproduction of the 30 safety and efficacy tables from the CDISC pilot study, rebuilt with a modern, open-source R reporting stack and rendered as Word (.docx) documents that are visually faithful to the original 2020 RTF outputs.
The stack
| Concern | Package |
|---|---|
| Table summaries (counts, descriptive stats, shifts) | tplyr2 |
| Table styling → DOCX | clinify |
| Mixed-model repeated measures (MMRM) | mmrm |
| Cochran–Mantel–Haenszel tests | coin |
| Data wrangling | tidyverse |
| Reproducible environment | renv |
Explore
- Outputs — browse all 30 tables, each with an in-page PDF viewer and downloads.
- Code Reference — the setup, helpers, shared builders, and every table program, with source.
- About — the original reproduction and the 2026 revisit.
Note
Every output is verified against the original RTF with a pixel-diff / content-diff fidelity harness. Where a value differs by design (e.g. modern MMRM vs. the legacy random-slope fit), the divergence is documented rather than cloned.